7-fold higher than that of raw domperidone (566
96E-012 mm Hg (25 deg C, Mod-Grain method) Water Solubility Estimate from Log Kow (WSKOW v1
It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms
7: ALOGPS: pKa (Strongest In the present work, the domperidone solubility, which has less study in the near-term, was reported, which was determined by the shake-flask method in twelve green solvents e
16 , 17 The solubility of domperidone in water is very low and is enhanced by the addition of surfactant (SLS)
00095 mg/ml in distilled water and 0
1-, and 3
Domperidone is a highly water insoluble drug exhibiting poor dissolution pattern
Binary systems of Domperidone were prepared with polyvinyl pyrrolidon
The low water solubility of DOM leads to a low According to Biopharmaceutical Classification System (BCS), domperidone is categorized under class II drugs due to poorly water-soluble and highly permeable [7] [8][9][10][11][12]
ABSTRACT Domperidone (DOM), an antidopaminergic medication, is primarily used as an antiemetic to treat nausea and vomiting caused by a variety of etiologies
The formulations comprise domperidone or pharmaceutically acceptable salts thereof, about 60 - 80% of a "auxiliary" granulate (w/w), and about 10 - 30% of microcrystalline cellulose (w/w), expressed in relation to the total weight of the tablets, a sweetener, a flavouring agent and a Domperidone is an antagonist at D2/3 receptors that is clinically used to treat nausea, induce prolactin release, and increase gastrointestinal transit speed
Shipping and Storage
From Authors: Background Domperidone (DOM), a dopamine receptor antagonist, is used as antiemetic for the treatment of gastroparesis, vomiting, and nausea
9)
The poor aqueous solubility may be one possible reason for its low bioavailability
Solid solubility is a significant physical property for a drug development and design
Solid solubility is a significant physical property for a drug development and design
24 µg/ml (Fig
9 so, it is a weakly-basic drug with a very poor dissolution rate at relatively- Since domperidone solubility is less, domperidone solid dispersion (DMP SD's) were prepared with β-cyclodextrine inclusion complexes in different ratio (1:1, 1:2, 1:3 and 1:4) by kneading This study was carried out to prepare and characterize domperidone nanoparticles to enhance solubility and the release rate
Dissolution data of inclusion complexes also indicated that there is 1
The complex formation capability of mixture LR-CDs having a degree of polymerization (DP) of 22-48, with DMP Cinnarizine: Practically insoluble in water
CO 2 is produced by the water-gas shift, which needs a great amount of CO
Oral transmucosal delivery of domperidone from immediate release films produced via hot-melt extrusion technology
Domperidone (DOM), a dopamine receptor antagonist, is used as antiemetic for the treatment of gastroparesis, vomiting, and nausea
Domperidone (5-chloro-1- (1- (3- (2-oxo-2,3-dihydro-1 H -benzo [ d ]imidazole-1-yl)propyl) piperidin-4-yl)-1,3-dihydro-2 H -benzo [ d ]imidazole-2-one), also
At the fixed
ijpharm
DOM was dissolved in appropriate solvent (acetone and methanol 1:1 v/v), and the stabilizing agent was dissolved in water (as nonsolvent)
9-, 13
Domperidone is a dopamine antagonist with antiemetic properties and has poor aqueous solubility (0
This could be
Introduction
decreasing metabolite production e
ABSTRACT Domperidone (DOM), an antidopaminergic medication, is primarily used as an antiemetic to treat nausea and vomiting caused by a variety of etiologies
The present invention relates to fast water-dispersible tablets containing domperidone for oral administration
2-fold higher than that of tablet
Domperidone is an antagonist at D2/3 receptors that is clinically used to treat nausea, induce prolactin release, and increase gastrointestinal transit speed
Shipping and Storage
134 mg/ml in distilled water and 3
Solvent deposition is a promising method to improve the solubility of poor EUROPEAN PHARMACOPOEIA 6
, solid dispersion, melt granulation, and weak base with good solubility in acidic pH but in alkaline pH, its solubility is significantly reduced10
LR-CDs contain a relatively hydrophobic cavity that is capable of entrapping the molecules to form inclusion complexes
In the present work, the domperidone solubility, which has less study in the near-term, was reported, which weak base with good solubility in acidic pH but in alkaline pH, its solubility is significantly reduced10
In the present work, the domperidone solubility, which has less study in the near-term, was reported, which Background: The domperidone maleate, a lipophilic agent classified as a Biopharmaceutical Classification System Class II substance with weak water solubility
This result is concordant with the solubility profile of domperidone in Since domperidone solubility is less, domperidone solid dispersion (DMP SD’s) were prepared with β-cyclodextrine inclusion complexes in different ratio (1:1, 1:2, 1:3 and 1:4) by kneading