This finding is consistent with the inhibition of PDE6, which is involved in phototransduction in the retina
Avanafil has a higher selectivity (120-fold) against PDE6 than sildenafil (16-fold) and vardenafil (21-fold), as well as a much higher selectivity (>10 000-fold) against
The difference in retinal effects between avanafil and sildenafil appears to be associated with selectivity for PDE5 against PDE6, which is present in retinal rod and
2012, The Journal
Avanafil is used to treat men who have erectile dysfunction (also called sexual impotence)
View Avanafil’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg
Our previous study showed that avanafil inhibits PDE5 with a 50% inhibitory concentration of 5
PDE5 inhibitors work to increase cGMP concentrations, which may therefore cause vasodilation and a
All experienced vision disturbances ranging from light sensitivity and blurriness to
The infection can be particularly severe in young children, infants, and immunocompromised
Avanafil, a PDE5 inhibitor, is highly selective for PDE5 and highly potent, with a 50% inhibitory concentration of 4
RP is a genetic disease (passed down from parents)
Avanafil did not induce myalgia, as is sometimes reported for tadalafil 18
More severe side effects, such as loss of vision and other vision-related issues, also appear more frequently among men who use
29–32 These
Research has shown that avanafil is less likely to cause some of the more troubling side effects of the earlier PDE5i, such as “blue” vision, an unsafe drop in blood pressure when combined with nitroglycerine, or hearing loss
Pharmacodynamics
Visual disorders such as functional blindness, blue (cynopsia) and blurred vision and enhanced light sensitivity have been attributed to the cross-reactivity with the PDE6 catalytic site, upon intake of PDE5